July 7, 2020 – Evolva is pleased to announce that the findings on bone mineral density of postmenopausal women in the RESHAW (Resveratrol Supporting Healthy Aging in Women) clinical study have been peer-reviewed and published in the Journal of Bone and Mineral Research. The report, “Regular Supplementation with Resveratrol Improves Bone Mineral Density in Postmenopausal Women,” is the second in the series of anticipated publications from the extensive two-year RESHAW clinical trial of Veri-te™ resveratrol in 125 postmenopausal women.
Conducted in Australia by Dr. Rachel Wong, Ms. Jay Jay Thaung Zaw, Professor Cory J Xian and Emeritus Professor Peter Howe at the University of Newcastle’s Clinical Nutrition Research Centre, RESHAW is the largest, longest-running study of its kind with resveratrol. Supported by the National Health and Medical Research Council and the Australian Research Council (NHMRC-ARC) and a grant from Evolva, RESHAW was designed to investigate the impact of resveratrol supplementation on body composition, including bone mineral density in critical regions, as well as measure biomarkers of bone metabolism. Additionally, cerebrovascular and cognitive befits have been reported in the first peer-reviewed publication. A wide range of secondary outcomes, including perceptions of wellbeing, physical function, and pain are yet to be published.
In the crossover comparison, volunteers were randomized to take two capsules containing 75mg of Evolva’s Veri-te™ resveratrol ingredient daily or a matching placebo supplement for 12 months, followed by the alternate treatment for a further 12 month-period. “We reported improved bone density in the lumbar spine and femoral neck of postmenopausal women, supported by a 7.2% relative reduction of plasma C-terminal telopeptide type-1 collagen, a marker of bone resorption,” commented NHMRC-ARC Dementia Research Fellow Dr. Wong. “When comparing the annual rate of decline of 0.96% in femoral neck bone mineral density in the elderly, the rate of decline of 0.34% in the femoral neck bone mineral density in the resveratrol group suggest the potential of resveratrol to reduce bone loss in ageing women,” said Dr. Wong.
Professor Peter Howe comments that “participants with greater bone resorption at baseline showed a greater reduction of plasma C-terminal telopeptide type-1 collagen with resveratrol, suggesting a greater potential for resveratrol to improve bone formation in those individuals at risk of rapid bone loss.” Professor Howe adds that “the increase in bone mineral density in the femoral neck resulted in an improvement in T-Score and a reduction in the 10-year probability of major and hip fracture risk.” It is important to note that “these benefits were observed in postmenopausal women without osteoporosis, and a sub-analysis suggests that resveratrol could be used synergistically with calcium plus Vitamin D supplements to further reduce the risk of total and hip fractures” adds Professor Howe.
“These first two peer-reviewed publications from the RESHAW clinical study provide the evidence that supplementation with Veri-te™ resveratrol should be a key strategy for the design of effective supplements that may lessen the decline in both brain and bone health as women age,” said Clare Panchoo, VP, Health Ingredients, Evolva. Furthermore, “the RESHAW reporting continues to point to the ability of resveratrol to improve the microcirculation and deliver blood to tissues, thereby supporting brain health and helping reduce bone loss as we age,” adds Panchoo.
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