New Study: Effects of Resveratrol on Men With Metabolic Syndrome

March 23rd, 2017 | Posted By: Clare Panchoo | Posted in News

Comprehensive Metabolomic Analysis in Blood, Urine, Fat, and Muscle in Men with Metabolic Syndrome: A Randomized, Placebo-Controlled Clinical Trial on the Effects of Resveratrol after Four Months’ Treatment

Anne Sofie Korsholm 1,*, Thomas Nordstrøm Kjær 1, Marie Juul Ornstrup 1 and Steen Bønløkke Pedersen 1
Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Institute of Clinical Medicine, Aarhus University, DK-8000 Aarhus C, Denmark
Correspondence: Tel.: +45-7846-7729
Academic Editors: Paula Andrade and Patrícia Valentão
Received: 6 January 2017 / Accepted: 26 February 2017 / Published: 4 March 2017

Abstract

Resveratrol possesses several beneficial metabolic effects in rodents, while the effects of resveratrol in humans remain unclear. Therefore, we performed a non-targeted comprehensive metabolomic analysis on blood, urine, adipose tissue, and skeletal muscle tissue in middle-aged men with metabolic syndrome randomized to either resveratrol or placebo treatment for four months. Changes in steroid hormones across all four matrices were the most pronounced changes observed. Resveratrol treatment reduced sulfated androgen precursors in blood, adipose tissue, and muscle tissue, and increased these metabolites in urine. Furthermore, markers of muscle turnover were increased and lipid metabolism was affected, with increased intracellular glycerol and accumulation of long-chain saturated, monounsaturated, and polyunsaturated (n3 and n6) free fatty acids in resveratrol-treated men. Finally, urinary derivatives of aromatic amino acids, which mainly reflect the composition of the gut microbiota, were altered upon resveratrol treatment. In conclusion, the non-targeted metabolomics approach applied to four different matrices provided evidence of subtle but robust effects on several metabolic pathways following resveratrol treatment for four months in men with metabolic syndrome—effects that, for the most part, would not have been detected by routine analyses. The affected pathways should be the focus of future clinical trials on resveratrol’s effects, and perhaps particularly the areas of steroid metabolism and the gut microbiome.

Keywords: resveratrol; natural bioactive agents; metabolic syndrome; metabolomics; metabolite profiling; gut microbiome; obesity; insulin sensitivity; inflammation
To see the full study click here: ijms-18-00554