Resveratrol: an ingredient for healthy ageing
Resveratrol is a polyphenol that is found in several types of plants. In grapes, resveratrol acts as a protector from the harsh environment. Scientific evidence suggests that it can do the same in humans working at a cellular level to assist healthy ageing. Published research and clinical data suggests that resveratrol can play a role in healthy ageing through bone health, cardiovascular health, blood glucose control, healthy cognitive function, skin youthfulness and oral health.
How Does Resveratrol Work?
Mitochondria are the powerhouses which make energy inside every cell in our bodies. As we age, mitochondrial function becomes slowly impaired. This leads to the decline of many systems in our body as we get older including cardiovascular, cognitive, skin and bone. Resveratrol has been shown to penetrate cells and help rejuvenate the mitochondria thus supporting healthier ageing. By working at this cellular level resveratrol is able to have a beneficial effect on many parts of the body. References.Learn More About How Resveratrol Works
Resveratrol has been shown in research studies to promote the formation of new-bone forming cells, which may lead to a beneficial effect on bone health. This action complements, rather than duplicates, the action of other bone supporting supplements, making resveratrol an important addition in bone health management.
Resveratrol continues to be the subject of numerous clinical studies in heart health. This research suggests that resveratrol may help the body’s cardiovascular system as it ages by supporting healthy blood flow, lowering total cholesterol, and reducing both diastolic and systolic blood pressure. Resveratrol may also have a beneficial effect on blood glucose management.
Resveratrol offers a powerful and scientifically-backed ingredient that can help rejuvenate and energise skin. Research suggests resveratrol may help reduce the intensity of age spots, improve skin elasticity and hydration, and protect against oxidative damage. In one clinical trial resveratrol was found to reduce the expression of certain pro-inflammatory cytokine genes. These genes are thought to be of major importance in the development of psoriasis. Research suggests that resveratrol may also help skin complaints such as mild acne.
Research indicates that resveratrol could be an effective ingredient in maintaining memory, processing, reasoning and executive function of the brain that may decline in older populations. Some of the beneficial effects of resveratrol that have been documented are increased blood flow to the brain and improved memory performance.
Made Like No Other
Veri-te™ resveratrol is produced using an innovative yeast fermentation process. This means our resveratrol is:
- PURE: >98% pure
- SAFE: free of contaminants (such as Emodin and PAHs)
- RELIABLE: consistent batch to batch
- VERSATILE: off-white, odourless and colourless
- > 98% pure food-grade for dietary supplements and foods and beverages
- Cosmetic-grade resveratrol with >99% purity
- API grade resveratrol product with DMF available. Sold as everesveratrol.
Regulatory & Quality Status:
- EU Novel Foods approved and US self-affirmed GRAS
- Made under cGMP and HACCP based food safety conditions
- Conforms to United States Pharmacopoeia
- Halal and Kosher certified resveratrol available
- We are a “Preferred vendor” of the National Animal Supplement Council (NASC).
Evolva is committed to supporting clinical trials and research studies to further understand the important benefits of resveratrol in human ageing.
Where to Buy
If you are interested in using Veri-te resveratrol for product formulation we’d love to hear from you.
You can either contact us directly here or use our online shop. We can provide a free 10g sample for testing. To receive this click on the Sample button below.
To buy our resveratrol online please click on the Web Shop button to register. As this is a service for business users only we will need to approve you to use the shop before you will be able to place an order (usually takes 24-48 hours).Get A Free Sample Visit Our Web Shop
Veri-te resveratrol is produced by Evolva. Evolva was founded in 2004 and today has operations worldwide. Based on a strong research foundation, we focus on producing high-value ingredients for use in applications for health, wellness and nutrition. We have an R&D team of around 120 scientists working on the cutting edge of their field. Evolva is a pioneer and global leader in sustainable, fermentation-based approaches. Our products include resveratrol, stevia, vanillin, valencene, nootkatone and saffron. Visit www.evolva.com to learn more.
1) Del Fattore A, Teti A and Rucci N. Bone cells and the mechanisms of bone remodelling. Front Biosci 2012;4:2302–2321.
2) Mobasheri A and Shakibaei M. Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis. Ann NY Acad Sci 2013;1290:59–66.
3) Ginaldi L, Di Benedetto MC and De Martinis M. Osteoporosis, inflammation and ageing. Immunity & Ageing 2005;2:14.
4) Poulsen MM, Fjeldborg K, Ornstrup MJ, Kjær TN, Nøhr MK, Pedersen SB. Resveratrol and inflammation: Challenges in translating pre-clinical findings to improved patient outcomes. Biochim Biophys Acta. 2015 Jun;1852(6):1124-36.
5) Ornstrup MJ, Harsløf T, Sørensen L, Stenkjær L, Langdahl BL, Pedersen SB. Resveratrol Increases Osteoblast Differentiation In Vitro Independently of Inflammation. Calcif Tissue Int. 2016 Aug;99(2):155-63.
6) Poulsen MM, Ornstrup MJ, Harsløf T, et al. Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men. J Funct Foods 2014;6:305–310.
1) Huang H, Chen G, Liao D et al. The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials. Obesity Reviews, 2016, doi: 10.1111/obr.12458.
2) Strandberg TE and Pitkala K. What is the most important component of blood pressure: systolic, diastolic or pulse pressure? Curr Opin Nephrol Hypertens 2003;12(3): 293-297.
3) Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011;14(5):612-622.
4) Movahed A, Nabipour I, Lieben Louis X, et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med 2013; Article ID 851267,2013. doi:10.1155/2013/851267.
5) Liu Y, Ma W, Zhang P, et al. Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials. Clin Nutr 2015;34(1):27-34.
6) Carrizzo A, Puca A, Damato A, et al. Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism. Hypertension 2013;62(2):359-366.
7) Black CD, Vickerson B and McCully KK. Noninvasive assessment of vascular function in the posterior tibial artery of healthy humans. Dynamic Med 2003;2:1.
8) Wong RH, Howe PR, Buckley JD, et al. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis 2011;21(11):851-856.
9) Militaru C, Donoiu I, Craciun A, et al. Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life. Nutrition 2013;29(1):178-183.
10) Tomé-Carneiro J, Gonzalvez M, Larrosa M, et al. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol 2012;110: 356-363.
11) Tomé-Carneiro J, Gonzalvez M, Larrosa M, et al. Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease. Cardiovasc Drugs Ther 2013;27(1):37-48.
1) Poljšak B and Dahmane R. Free Radicals and Extrinsic Skin Aging. Dermatol Res Pract. 2012, 135206 (2012).
2) Farris, P. et al. Resveratrol : A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin. J Drugs Dermatol. 12,1389-1394. (2013).
3) Buonocore, D. et al. Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo- controlled , double-blind study. Clin Cosmet Investig Dermatol. 5, 159–165 (2012).
4) Britton, R. G., Kovoor, C. and Brown, K. Direct molecular targets of resveratrol : identifying key interactions to unlock complex mechanisms. Ann N Y Acad Sci. 1348, 124–133 (2015).
5) Bernard, P. and Berthon, J. Resveratrol : an original mechanism on tyrosinase inhibition. Int J Cosmet Sci. 22, 219–226 (2000).
6) Lee, T. H. et al. Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin. Biomol Ther (Seoul). 22,35-40 (2014).
7) Coenye, T. et al. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine. 19, 409–412 (2012).
8) Kim, S. O. Y. et al. Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K / Akt pathway. Int J Mol Med. 35, 1042–1050 (2015).
9) Fabbrocini, G. and Study, P. Resveratrol-Containing Gel for the Treatment of Acne Vulgaris Resveratrol-Containing Gel for the Treatment of Acne Vulgaris. Am J Clin Dermatol. 12,133-141 (2011).
10) Poulsen, M. M. et al. Resveratrol and inflammation: Challenges in translating pre-clinical fi ndings to improved patient outcomes. Biochimica et Biophysica Acta 1852, 1124–1136 (2015).
11) Kjær, T. et al. Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. PLoS One. 10, 1–18 (2015).
1) Deary, I. J. et al. Age-associated cognitive decline. Br. Med. Bull. 92, 135–152 (2009).
2) Kirk-Sanchez, N. J. & McGough, E. L. Physical exercise and cognitive performance in the elderly: current perspectives. Clin. Interv. Aging 9, 51–62 (2014).
3) Barclay, L. Life Extension. 13, 2, 56 (2007). http://www.lifeextension.com/Magazine/2007/2/report_cognitex
4) Williams, K. and Kemper, S. Exploring Interventions to Reduce Cognitive Decline in Aging. J Psychosoc Nurs Ment Health Serv. 10, 550–567 (2011).
5) Witte, A. V., Kerti, L., Margulies, D. S. & Flöel, A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neurosci. 34, 7862–70 (2014).
6) Witte, A. V., et al. Impact of Resveratrol on Brain Function and Structure. ClinicalTrials.gov Identifier: NCT02621554 (2017).
7) Kennedy, D. O. et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover. Am. J. Clin. Nutr. 91, 1590–1597 (2010).
8) Wightman, E. L. et al. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br. J. Nutr. 112, 203–213 (2014).
9) Wightman, E. L. et al. The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans. Br. J. Nutr. 114, 1427–1437 (2015).
10) Evans, H. M. et al. Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial. Nutrients 9, 27 (2017).
11) Turner, R. S. et al. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology 85, 1383–1391 (2015).
12) Moussa, C. et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer ’ s disease. J. Neuroinflammation 14, 1–10 (2017).
13) Howe, P. et. al. Effect of 12-month daily resveratrol supplementation on brain health in post-menopausal women. Trial ID : ACTRN12616000679482p (2017).
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